Welcome, M.Sc. Chemistry students specializing in Organic Chemistry at Osmania University! Navigating the new CBCS (2023-24 onwards) syllabus for the Third Semester can be challenging. This detailed guide breaks down every core and elective paper, providing you with a clear roadmap to 100% preparation and top marks.
We cover Synthetic Reagents, Modern Organic Synthesis, Spectroscopic Techniques (2D NMR), Bioorganic Chemistry, Process Chemistry, and Green Chemistry.
Core Papers: Mastering the Foundation
The core papers are crucial for your specialization. Focus heavily on these subjects.
Paper I: CH(OC) 301T: Synthetic Reagents, C-13 and 2D NMR
This paper blends advanced synthesis tools with cutting-edge analytical techniques.
| Unit | Topic Focus | Key Concepts to Master |
| OC-07 | Synthetic Reagents-I (Protection & Organometallics) | Protecting Groups: Alcohols (silyl ethers, esters), Diols (acetals, ketals), Amines (BOC, FMOC), Carbonyls (thiol acetals / Umpolung). Organometallic Reagents: Organolithium, Organocopper, Organoboranes. Wittig and Horner-Wordsworth-Emmons reactions. Rh-catalyzed C-H Activation. |
| OC-08 | Synthetic Reagents-II (Oxidation & Reduction) | Oxidation: DDQ, SeO2, Prevost/Woodward diol formation. Alcohol oxidation (PCC, PDC, Swern, DMP, TEMPO). Reduction: Homogeneous (Wilkinson’s) and Heterogeneous Catalytic Hydrogenation. Birch reduction. Nucleophilic (LiAlH4, NaBH4) and Electrophilic (BH3, DIBAL) hydrides. Tri-n-butyl tin hydride (Radical reductions). |
| OC-09 | C-13 NMR and 2D NMR Spectroscopy | C-13 NMR: Proton-decoupled vs. off-resonance decoupled (ORD). Factors affecting chemical shifts, shift calculation (alkanes, alkenes, alkynes). Spectral Editing: APT, INEPT, DEPT methods. 2D NMR: Principles, COSY (H-H), TOCSY, Hetero COSY (HMQC, HMBC). NOESY. |
Paper II: CH(OC) 302T: Modern Organic Synthesis
This paper is dedicated to the core strategies and novel reactions used in constructing complex organic molecules.
| Unit | Topic Focus | Key Concepts to Master |
| OC-10 | Asymmetric Synthesis | Stereoselectivity: Prostereoisomerism (Re/Si faces), Cram’s rule, Felkin-Anh model. Enantioselectivity Control: Chiral Substrate, Auxiliary (Evan’s oxazolidinone), Reagent (BINAL-H, IPCBH2), and Catalyst (Sharpless epoxidation, Asymmetric Hydrogenation). Zimmerman-Traxel model for Aldol. |
| OC-11 | Synthetic Strategies (Retrosynthesis) | Retrosynthetic Analysis: Target, Synthon, Synthetic Equivalent. FGI. Linear vs. Convergent Synthesis. Disconnections: One- and Two-group C-C and C-X disconnections. Diels-Alder, Michael addition, Robinson annulation. Strategic bond guidelines. |
| OC-12 | New Synthetic Reactions | Metal-Mediated Coupling: Suzuki, Heck, Stille, Sonogishira, Buchwald-Hartwig. C-C Formation: Shapiro, Bamford-Stevens, McMurrey reactions. Julia-Lythgoe olefination. Metathesis: Grubb’s catalysts, RCM (Ring Closing Metathesis). Click Chemistry. |
Elective Papers: Advanced & Applied Organic Chemistry
You choose one elective from Group III and one from Group IV.
Elective III Options (CH(OC) 303T)
| Option (A) | Option (B) |
| Bioorganic Chemistry and Conformational Analysis | Process Chemistry and Development |
| OC(CB1)-13: Carbohydrates, Nucleic acids & Coenzymes (Structure, function, synthesis, TPP, NADPH) | OC(CB1)-13: Process Chemistry and Principles (SELECT criteria: Safety, Environment, Legal, Economics, Control, Throughput. Route Selection.) |
| OC(CB1)-14: Proteins, Enzymes and Lipids (Peptide synthesis, Lock and Key model, Enzyme selectivity, Lipid biosynthesis) | OC(CB1)-14: Process Development / Optimization – I (Process Safety, DSC/TSU reaction calorimetry, Analytical monitoring: HPLC, GC. Impurity identification, Fixing specifications) |
| OC(CB1)-15: Conformational Analysis-II & ORD/CD (Cyclic systems: Cyclohexane derivatives, Decalins, Piperidine, Tropine. Cotton effect and applications of ORD/CD in structure determination) | OC(CB1)-15: Process Development / Optimization – II (Reaction Kinetics, Work-up, Isolation, Purification (Crystallization). Drying methods (VTD, FBD). Finalizing CPPs and CMAs.) |
Elective IV Options (CH(OC) 304T)
| Option (A) | Option (B) |
| Green Chemistry and New Techniques | Pesticides |
| OC(CB2)-16: Principles of Green Chemistry and Green Synthesis (12 Principles, MAOS (Microwave), Ultrasound, Ionic Liquids, Aqueous Phase Reactions, PTC, Biocatalysis) | OC(CB2)-16: Introduction to Pesticides (Classification, Pest Control Methods, Pheromones, Juvenile Hormones, Pollution, Formulations) |
| OC(CB2)-17: Organic Nanomaterials and Supramolecular Chemistry (Fullerenes, CNTs, Graphenes. Host-Guest Chemistry (Cryptands, Cyclodextrins), Self-assembly) | OC(CB2)-17: Synthetic Insecticides (Organochlorine, Organophosphorous, Carbamate insecticides. Pyrethroids. Natural origin: Rotenone, Azadirachtin) |
| OC(CB2)-18: New Techniques and Concepts (Solid Phase Peptide/Oligonucleotide Synthesis. Glycosidation, Tandem Synthesis, Baldwin Rules, Chiron Approach) | OC(CB2)-18: Natural Insecticides & Herbicides (Fungicides (Quinones, Benzimidazoles), Rodenticides (Warfarin), Herbicides (2,4-D, Carbamates, Urea derivatives)) |
Practical Courses (Laboratory Work)
These labs are designed to cement your theoretical knowledge with hands-on skill development.
| Paper | Focus Areas |
| CH(OC) 351P | Synthesis of Organic Molecules: Multi-step synthesis involving named reactions (Fischer Indole, Fries, Sandmeyer, Beckmann rearrangement, NaBH4 reduction). |
| CH(OC) 352P | Separation and Identification of Organic Compounds: Separation of two-component mixtures (acid/base/neutral) by chemical methods (solvent extraction). Systematic qualitative analysis and derivative preparation. |
| CH(OC) 353P | Isolation of Natural Products and Thin Layer Chromatography: Isolation of Caffeine, Piperine, Eucalyptus oil. Purity checking and component identification using TLC. |
| CH(OC) 354P | Separation of Three Component Mixtures & Column Chromatography: Separation of three-component mixtures by chemical methods. Separation of mixtures by Column Chromatography, monitored by TLC. |
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To absolutely dominate your M.Sc. Organic Chemistry 3rd Semester exams at Osmania University, you need the right tools.
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- Detailed Revision Notes on all core topics (C-13 NMR and 2D NMR, Retrosynthesis, Green Chemistry).
- Important Questions and Previous Question Paper analyses for all subjects.
- High-Yield Study Material to ensure the best possible rank!
Click below to instantly download your FREE M.Sc. Organic Chemistry III Semester PDF Study Pack!
[DOWNLOAD FREE OU M.Sc. ORGANIC CHEMISTRY 3RD SEM NOTES & PREVIOUS PAPERS PDF HERE]
Disclaimer: This syllabus guide is based on the M.Sc. Chemistry CBCS Structure (2023-24 onwards) for Osmania University. Always refer to your official department circular for the final elective choices.